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Replication of 2 subtypes of low-pathogenicity avian influenza virus of duck and gull origins in experimentally infected mallard ducks

机译：在实验感染的野鸭中复制2种低致病性鸭和禽源禽流感病毒亚型

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Many subtypes of low-pathogenicity avian influenza (LPAI) virus circulate in wild bird reservoirs, but their prevalence may vary among species. We aimed to compare by real-time reverse-transcriptase polymerase chain reaction, virus isolation, histology, and immunohistochemistry the distribution and pathogenicity of 2 such subtypes of markedly different origins in Mallard ducks (Anas platyrhynchos): H2N3 isolated from a Mallard duck and H13N6 isolated from a Ring-billed Gull (Larus delawarensis). Following intratracheal and intraesophageal inoculation, neither virus caused detectable clinical signs, although H2N3 virus infection was associated with a significantly decreased body weight gain during the period of virus shedding. Both viruses replicated in the lungs and air sacs until approximately day 3 after inoculation and were associated with a locally extensive interstitial, exudative, and proliferative pneumonia. Subtype H2N3, but not subtype H13N6, went on to infect the epithelia of the intestinal mucosa and cloacal bursa, where it replicated without causing lesions until approximately day 5 after inoculation. Larger quantities of subtype H2N3 virus were detected in cloacal swabs than in pharyngeal swabs. The possible clinical significance of LPAI virus-associated pulmonary lesions and intestinal tract infection in ducks deserves further evaluation.
机译：低致病性禽流感（LPAI）病毒有许多亚型在野生鸟类水库中传播，但它们的流行程度可能因物种而异。我们旨在通过实时逆转录酶聚合酶链反应，病毒分离，组织学和免疫组织化学来比较野鸭（Anas platyrhynchos）中两种明显不同来源的亚型的分布和致病性：从野鸭和H13N6中分离出的H2N3分离自环嘴鸥（Larus delawarensis）。气管内和食管内接种后，尽管H2N3病毒感染与病毒脱落期间体重增加显着降低有关，但两种病毒均未引起可检测的临床体征。两种病毒均在肺和气囊中复制，直到大约接种后第3天，并与局部广泛的间质性，渗出性和增生性肺炎有关。 H2N3亚型，而不是H13N6亚型，继续感染肠粘膜和泄殖腔囊上皮，在感染后大约第5天，它在没有引起损害的情况下复制。泄殖腔拭子中检出的H2N3亚型病毒数量多于咽拭子。鸭中LPAI病毒相关的肺部病变和肠道感染的可能临床意义值得进一步评估。

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